B7 membrane protein family by ACROBiosystems
Co-stimulatory and co-inhibitory checkpoint proteins
Our innate immune system is an intricate checks and balances system that incorporates numerous positive and negative co-stimulatory molecules. In particular, the B7 membrane protein family has shown to play a collaborative role in regulating T cell responses, either transmitting the ‘second’ signal in tandem with CD28 or CTLA-4 to stimulate T cell proliferation, T cell differentiation, inhibit immune responses, or induce antigenic tolerance. Depending on the receptor interaction, T lymphocyte mediated immune response can be either inhibited or stimulated.

Currently, the B7 membrane protein family includes 11 members, listed below:
Name | Alt. Name | Binds to |
---|---|---|
B7-1 | CD80 | CD28, CTLA-4, PD-L1 |
B7-2 | CD86 | CD28, CTLA-4 |
B7-DC | PD-L2, CD273 | PD-1 |
B7-H1 | PD-L1, CD274 | PD-1 |
B7-H2 | ICOSLG, CD275 | ICOS |
B7-H3 | CD2765 | |
B7-H4 | VTCN1 | |
B7-H5 | VISTA | |
B7-H6 | NCR3LG1 | NKp30 |
B7-H7 | HHLA2 | CD28H |
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